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BASIC AND TRANSLATIONAL RESEARCH PROGRAM
Alotaibi Lab. Angelov Lab. Atabey Lab. Gene Targeting and Transgenic Models Platform Genc Lab. Kale Lab. Karaca Lab. Oktay Lab. Ozhan Lab. Pavlopoulou Lab. Sag Lab. Senturk Lab. Wingender Lab. MG Lab. THORLAB Erkek Lab. BG Lab. Özbek Lab.

Group Members

Angelov Lab. on Chromatin and Repair





  1. Angelov Lab. on Chromatin and Repair

Tuğçe BATUR Researcher  tugce.batur@ibg.edu.tr


Imtiaz Nisar LONE Researcher  imtiaznisar.lone@ibg.edu.tr


Ece Şule ZANGUR MSc Student  ece.zangur@ibg.edu.tr


Ezgi BATU Undergraduate Student  ezgi.batu@std.ibg.edu.tr


Former Members

Dimitar ANGELOV Research Group Leader  dimitar.angelov@ibg.edu.tr


Serhan TURUNÇ PhD Student  serhan.turunc@ibg.edu.tr


ABED ALKAREM ABU AL HAIJA PhD Student  abedalkarem.hani@ibg.edu.tr


Helin SAĞIR PhD Student  helin.sagir@ibg.edu.tr


Khalid ABDALLA Researcher  khalid.abdalla@ibg.edu.tr


Selected Publications

Abu Alhaija AA, Lone IN, Ozkuru Sekeroglu E, Batur T, Angelov D, Dimitrov S, Hamiche A, Firat Karalar EN, Ercan ME, Yagci T, Alotaibi H, Diril MK. Development of a mouse embryonic stem cell model for investigating the functions of the linker histone H1-4.. FEBS open bio. 2024 February . doi:10.1002/2211-5463.13750.

Cadet J, Angelov D, Wagner JR. Hydroxyl radical is predominantly involved in oxidatively generated base damage to cellular DNA exposed to ionizing radiation.. International journal of radiation biology. 2022 May : 1-7. doi:10.1080/09553002.2022.2067363.

Angelov D, Lone IN, Menoni H, Cadet J. Interstrand Crosslinking Involving Guanine: A New Major UVC Laser-Induced Biphotonic Oxidatively Generated DNA Damage.. Photochemistry and photobiology. 2022 May ; 98 (3) : 662-670. doi:10.1111/php.13587.

Boopathi R, Danev R, Khoshouei M, Kale S, Nahata S, Ramos L, Angelov D, Dimitrov S, Hamiche A, Petosa C, Bednar J. Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends.. Nucleic acids research. 2020 June ; 48 (10) : 5735-5748. doi:10.1093/nar/gkaa246.

Shukla, MS; Syed, SH; Boopathi, R; Ben Simon, E; Nahata, S; Ramos, L; Dalkara, D; Moskalenko, C; Travers, A; Angelov, D; Dimitrov, S; Hamiche, A; Bednar, J. Generation of Remosomes by the SWI/SNF Chromatin Remodeler Family. Scientific Reports. 2019 October ; 9 . doi:10.1038/s41598-019-50572-8.

Cadet J, Wagner JR, Angelov D. Biphotonic Ionization of DNA: From Model Studies to Cell. Photochemistry and Photobiology. 2019 January ; 95 (1) : 59-72. doi:10.1111/php.13042.

Torben Schindler, Adrián González, Ramachandran Boopathi, Marta Marty Roda, Lorena Romero-Santacreu, Andrew Wildes, Lionel Porcar, Anne Martel, Nikos Theodorakopoulos, Santiago Cuesta-López, Dimitar Angelov, Tobias Unruh, and Michel Peyrard. Kinky DNA in solution: Small-angle-scattering study of a nucleosome positioning sequence. Phys Rev E. 2018 October ; 98 : 04241. doi:10.1103/PhysRevE.98.042417.

I. Garcia-Saez, H. Menoni, R. Boopathi, M. S. Shukla, L. Soueidan, M. Noirclerc-Savoye, A. Le Roy, D. A. Skoufias, J. Bednar, A. Hamiche, D. Angelov¶, C. Petosa¶, S. Dimitrov¶. Structure of an H1-Bound 6-Nucleosome Array Reveals an Untwisted Two-Start Chromatin Fiber Conformation. Mol Cell. 2018 December ; 72 (5) : 902-912 E7. doi:10.1016/j.molcel.2018.09.027.

Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A, Hayes JJ, Schultz P, Angelov D, Petosa C, Dimitrov S. Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1.. Molecular cell. 2017 May ; 66 (3) : 384-397.e8. doi:10.1016/j.molcel.2017.04.012.

Menoni H, Di Mascio P, Cadet J, Dimitrov S, Angelov D. Chromatin associated mechanisms in base excision repair - nucleosome remodeling and DNA transcription, two key players.. Free radical biology & medicine. 2017 June ; 107 : 159-169. doi:10.1016/j.freeradbiomed.2016.12.026.

Roulland Y, Ouararhni K, Naidenov M, Ramos L, Shuaib M, Syed SH, Lone IN, Boopathi R, Fontaine E, Papai G, Tachiwana H, Gautier T, Skoufias D, Padmanabhan K, Bednar J, Kurumizaka H, Schultz P, Angelov D, Hamiche A, Dimitrov S. The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity.. Molecular cell. 2016 August ; 63 (4) : 674-685. doi:10.1016/j.molcel.2016.06.023.

Lahmy S, Pontier D, Bies-Etheve N, Laudié M, Feng S, Jobet E, Hale CJ, Cooke R, Hakimi MA, Angelov D, Jacobsen SE, Lagrange T. Evidence for ARGONAUTE4-DNA interactions in RNA-directed DNA methylation in plants.. Genes & development. 2016 December ; 30 (23) : 2565-2570. doi:10.1101/gad.289553.116.

Charles Richard JL, Shukla MS, Menoni H, Ouararhni K, Lone IN, Roulland Y, Papin C, Ben Simon E, Kundu T, Hamiche A, Angelov D, Dimitrov S. FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC.. PLoS genetics. 2016 July ; 12 (7) : e1006221. doi:10.1371/journal.pgen.1006221.

Total : 13

Projects

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Repair of DNA Damage in Rahman Syndrome, Ongoing

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Mechanism of Linker Histone H1-Mediated Chromatin Folding Under Normal and Diseases Conditions, Ongoing

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Sağlıkta ve Rahman Sendromunda Bağlayıcı Histon H1E, Ongoing

Contact

Angelov Lab. on Chromatin and Repair