Ayar-Kayali Lab. on Biopharmaceutic Technologies and Bioanalysis
OVERVIEW
Our studies till today, we have continued to clarify the PKC signal pathway, the results from these studies will guide our new projects. We found that EpCAM, Claudin and tetraspanin are the important proteins that have been found effective in the signaling pathway.
Following this project, studies on the effect of exosomes released from ovarian cancer cells by primary ovarian cancer cells and healthy epithelium and mesothelial cells by uptake of 1001 Tubitak Project and carcinogenesis mechanism in target cells are continuing.
According to the results obtained from these studies, it is aimed to improve the diagnosis and treatment of ovarian and colon cancer. In this context, synthesis of targeted therapeutic molecules, development of diagnostic kits optimized for diseases and cancer, and full characterization of synthesized molecules are studied.
RESEARCH INTERESTS
1. Development of the Smart (Targeted) Chemotherapeutic Agents and Drug Delivery System
The selective delivery of highly effective drugs by antibody drug conjugates (ADC) is a promising approach for the treatment of cancer to overcome the multidrug resistance (MDR). The monoclonal antibody (mAb), which has been highly expressed by specific cancer type, may be linked to payload which targets the DNA or microtubules using the site-specific conjugation methods to synthesize the ADC. Both the use of the target antibody and the use of a hydrophilic linker may help to overcome the MDR. In addition, we are planning to produce surface functionalized exosome (mAb-exosome, drug-exosome, peptide-exosome conjugates) loaded drug for specific targeting.
2. Development of the Diagnosis Kits
In this content, it is tried to find specific biomarkers for rare diseases and cancer. The biological nanovesicles, namely exosomes which include some specific proteins called “Exosome Markers”. The study aims to develop diagnostic kit based on exosome to help diagnose cancer types at an early stage and also determine the stage of the cancer by using statistical algorithms. The specific biomarker in the patient’s blood samples will be screened by using Exosome-mAb/Drug/Peptide Conjugation.
Group Members
Ayar-Kayali Lab. on Biopharmaceutic Technologies and Bioanalysis
Research Group Leader
Hülya AYAR KAYALI
hulya.kayali@ibg.edu.tr
+90 232 299 41 00
(5081)
+9
0 232 299 41 58
Gizem YILMAZER ALTUN
R&D Personnel
gizem.yilmazer@ibg.edu.tr
Aytaj ABUSHOVA
PhD Student
aytaj.abushova@ibg.edu.tr
Ege Gökçe SAVAŞ
PhD Student
ege.savas@ibg.edu.tr
Oğuzhan AVCI
Undergraduate Student
oguzhan.avci@ibg.edu.tr
Fethican KAYHAN
MSc Student
fethican.kayhan@ibg.edu.tr
Enes GÜNDÜZ
Undergraduate Student
enes.gunduz@ibg.edu.tr
Duygu ERDOĞAN
PhD Student
duygu.erdogan@ibg.edu.tr
Mariam J. M GHUNAIM
PhD Student
mariam.ghunaim@ibg.edu.tr
Ezgi İTİL
PhD Student
ezgi.itil@ibg.edu.tr
Zeynep ÖNCÜ
Undergraduate Student
zeynep.oncu@ibg.edu.tr
Ekrem TINAZ
Researcher
ekrem.tinaz@ibg.edu.tr
Yonca GÜNGÖR
PhD Student
yonca.gungor@ibg.edu.tr
Cengiz Han YAVUZ
Undergraduate Student
cengiz.yavuz@ibg.edu.tr
Defne GÖVEM
MSc Student
defne.govem@ibg.edu.tr
Onur ÖZKAYA
MSc Student
onur.ozkaya@ibg.edu.tr
Elçin ÇAĞATAY
PhD Student
elcin.cagatay@ibg.edu.tr
İlayda KELEŞ
MSc Student
ilayda.keles@ibg.edu.tr
Muzaffer DÜKEL
Visiting Researcher
muzaffer.dukel@ibg.edu.tr
Former Members
PUMLA BHEKIWE MANYATSI
PhD Student
pumlabhekiwe.manyatsi@ibg.edu.tr
Ekrem TINAZ
Visiting Researcher
ekrem.tinaz@ibg.edu.tr
Gizem YILMAZ
MSc Student
gizem.yilmaz@msfr.ibg.edu.tr
Esra BULUT
Visiting Researcher
esra.bulut@ibg.edu.tr
Yiğit KOZALI
MSc Student
yigit.kozali@ibg.edu.tr
Gamze ÜNER
Visiting Student
None
Hezzal KÜÇÜKSELBES
Undergraduate Student
hezzal.kucukselbes@ibg.edu.tr
Elçin ÇAĞATAY
Researcher
elcin.cagatay@ibg.edu.tr
Elçin ÇAĞATAY
PhD Student
elcin.cagatay@ibg.edu.tr
Egemen Erdem GÜLER
PhD Student
egemen.guler@ibg.edu.tr
Gizem KURŞUNOĞLU
Researcher
gizem.kursunluoglu@ibg.edu.tr
Ayşe CAŞKIR
MSc Student
ayse.caskir@ibg.edu.tr
Seminay GÜLER
PhD Student
seminay.guler@ibg.edu.tr
Aziz Umut DURAK
MSc Student
umut.durak@ibg.edu.tr
Zehra TAVŞAN
Post-Doc Researcher
zehra.tavsan@msfr.ibg.edu.tr
Buse SEVGİ
MSc Student
buse.sevgi@ibg.edu.tr
Gaye SAYGI
Visiting Researcher
gaye.saygi@ibg.edu.tr
Gülnur ÇIRAK
MSc Student
gulnur.cirak@msfr.ibg.edu.tr
İlyas Umur AYAZ
Researcher
umur.ayaz@ibg.edu.tr
Projects
The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Ovaryum Kanserinde Tetraspain-Claudin-Epcam Tümör Belirleyici Proteinlerinin ve Protein Kinaz C'nin Rolünün Belirlenmesi, Finished
The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Kanser ve Osteoporoz Tedavisi İçin Monoklonal Antikor Etkin Maddeli Biyobenzer İlaç Geliştirilmesi ve Üretilmesi, Ongoing
DEÜ BAP - Dokuz Eylul University Scientific Research Projects Coordination Unit - RD : Kolon Kanserinde Etkin Bazı Yolaklar Üzerine PKC İzoenzim Aktivitelerinin Etkisinin in vitro İncelenmesi, Finished
The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Ovaryum Kanser Hücrelerinden Salınan Eksozomların Primer Ovaryum Kanser Hücreleri İle Sağlıklı Epitel Ve Mezotel Hücreler Tarafından Alınım Yolları Ve Hedef Hücrelerdeki Karsinojenez Mekanizmasına Etkisi, Finished
The Scientific and Technological Research Council of Turkey - TUBITAK - RD : TCA Döngüsü ve Glikoliz Yolağındaki Metabolit Seviyelerinin Farklı Aşamalardaki Kolon Kanseri Hücre Hatlarında HPLC Yöntemi ile İncelenmesi, Finished
The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Çoklu İlaç Dirençli Yumurtalık Kanser Tedavisine Yönelik Terapötik Antikor-İlaç Konjugatı Sentezi ve Karakterizasyonu, Ongoing
Contact
Ayar-Kayali Lab. on Biopharmaceutic Technologies and Bioanalysis
Research Group Leader
Hülya AYAR KAYALI
hulya.kayali@ibg.edu.tr
+90 232 299 41 00
(5081)
+9
0 232 299 41 58